You have probably heard the buzz around ozone and blood treatments, and you may be unsure what is real and what is hype. That skepticism is healthy. EBOO is one of the more advanced wellness therapies we offer, and it deserves a clear, honest explanation rather than a sales pitch. EBOO stands for Extracorporeal Blood Oxygenation Ozonation and Filtration, and it is an advanced form of IV ozone therapy that filters and oxygenates the blood at the same time using a specialized device.
EBOO is one of the more advanced wellness therapies in our clinic, and it deserves a clear, honest explanation rather than a sales pitch. This guide covers what EBOO therapy is, how the IV ozone process works, who is and is not a candidate, the potential benefits, the side effects and risks, how it compares with simpler ozone methods, and what treatment costs. We treat EBOO as a clinical decision, not a default, so the most important part of this page is helping you understand whether it is even right for you.
What Is EBOO Therapy?
Answer: EBOO, short for Extracorporeal Blood Oxygenation Ozonation and Filtration, is an advanced form of IV ozone therapy. A specialized device draws your blood through a sterile filter while adding an oxygen-ozone mixture, then returns the treated blood to your body, so filtration and oxygenation happen at the same time.
Because EBOO filters and ozonates simultaneously, it allows greater continuous oxygen-ozone exposure than simpler IV ozone methods. The simultaneous filtration is what distinguishes EBOO from a basic ozone infusion. At AgeRejuvenation, the most important part of EBOO is not the device, it is the screening that happens before it. Ozone therapies are not appropriate for everyone, so our providers review your health history and goals first and tell you honestly whether EBOO is a reasonable option. A clinical review of medical ozone explains how medical ozone therapy is used and studied, and it is worth reading alongside any consultation.
How Does EBOO Therapy Work?
Answer: During EBOO, blood is gently circulated out through a sterile, single-use circuit, passed across a filter, and exposed to a controlled oxygen-ozone gas before being returned to your circulation, all in one continuous loop over the session.
The closed circuit keeps the process sterile from start to finish, and the ozone is delivered into the blood through a gas-exchange membrane rather than injected directly. Because the blood is moving continuously, the oxygen-ozone contact is steady rather than a single bolus. The proposed rationale for ozone therapies centers on oxidative signaling and antioxidant response, the same biology behind the role antioxidants play against cell damage. The science in humans is still developing, so we describe what EBOO is designed to support without overstating it.
Who Is a Candidate for EBOO Therapy?
Answer: EBOO is generally explored by patients focused on circulation, recovery, and oxidative-stress support, but candidacy is decided individually. Some patients are good candidates and some are not, and certain conditions make ozone-based therapy a poor fit.
Ozone-based care is not appropriate for everyone, which is why a screening comes first. People with specific blood disorders, certain enzyme deficiencies such as G6PD deficiency, uncontrolled cardiovascular or thyroid conditions, or those who are pregnant are generally not candidates, and any active medication or health concern is reviewed before treatment. We confirm fit with a provider rather than treating everyone who asks, because responsible candidacy review is the core of safe ozone care.
What Are the Potential Benefits of EBOO?
Answer: Patients typically pursue EBOO for general circulation, recovery, and oxidative-stress support, framed conservatively. We present EBOO as one option among several rather than a cure, and we pair it with diagnostics that clarify your baseline.
Reported interest in ozone therapies centers on oxygenation, immune signaling, and recovery support, areas the published literature continues to study. We frame any expected benefit individually and with realistic timelines, and we are clear about what EBOO is designed to support and what it is not. If a simpler approach is likely to serve your goals just as well, we will say so. The aim is an honest assessment, not a hard sell.
What Are the Side Effects and Risks of EBOO?
Answer: Most patients tolerate EBOO well, but ozone therapies carry real risks, including lightheadedness, fatigue, a reaction at the IV site, and, rarely, more serious events. Ozone is also a respiratory irritant, so it is never inhaled during treatment.
Common, usually mild effects can include temporary tiredness, lightheadedness, or discomfort at the access site. Because ozone irritates the airways, the EPA notes why ozone is irritating to the lungs when inhaled, which is exactly why EBOO delivers ozone only into a closed blood circuit and never as a gas you breathe. More serious risks are uncommon and are minimized by careful screening, sterile technique, and provider supervision throughout the session. This is the reason we screen first rather than treating on request.
EBOO vs. Standard IV Ozone Therapy
Answer: EBOO filters and ozonates the blood at the same time in a continuous circuit, while standard IV ozone methods such as major autohemotherapy treat a smaller, fixed volume of blood in a single batch.
The table below outlines the practical differences. The right method depends on your goals, your candidacy, and what your provider judges appropriate, not on the most aggressive option available.
| Feature | EBOO | Standard IV ozone (major autohemotherapy) |
|---|---|---|
| Process | Continuous loop that filters and ozonates at once | Single batch of withdrawn blood is ozonated, then returned |
| Blood volume | Larger, circulated continuously through the device | Smaller, fixed volume per treatment |
| Filtration | Yes, an integrated filter is part of the circuit | Typically none |
| Session length | About 60 to 90 minutes | Usually shorter |
| Best considered for | Patients seeking the more advanced, filtered approach | Patients exploring a simpler entry to ozone therapy |
What Should I Expect During an EBOO Session?
Answer: Expect a consultation and screening first, then a treatment that typically runs about 60 to 90 minutes, during which you are seated comfortably while your blood is circulated through the device and returned to you.
You will have an IV placed, and the device handles the filtration and oxygenation while a provider monitors the session. Most people rest, read, or relax throughout. Your provider confirms timing and how many sessions, if any, make sense for your goals, since a session count is determined individually rather than sold as a fixed package.
How Much Does EBOO Therapy Cost?
Answer: EBOO is a self-pay wellness therapy and is not typically covered by insurance, and the cost depends on your plan and the number of sessions, which is set individually.
Because plans are individual, we review exact costs during your consultation so there are no surprises before you begin. We would rather you understand the full picture, including whether a simpler option might suit you, than commit to a package that does not fit your goals.
Why Choose AgeRejuvenation for EBOO Therapy?
Answer: Advanced therapies demand judgment, which an unscreened, walk-in approach lacks. We treat EBOO as a clinical decision, with screening, honest counseling, and coordination across your broader care.
Our work is led by Chief Medical Director Dr. Dawn Ericsson, MD, alongside a team experienced in advanced IV and wellness therapies. Our clinical team was trained directly by Dr. Joseph Purita, MD, the developer of EBO2 (Extracorporeal Blood Oxygenation and Ozonation, commonly known as EBOO). Dr. Purita is a board-certified orthopedic surgeon and an internationally recognized leader in regenerative medicine, ozone therapy, stem cell treatments, and platelet-rich plasma. Because our providers learned the protocol from its developer, the EBOO you receive follows the method as it was designed, not a secondhand adaptation. EBOO is one part of our complete program of advanced IV and wellness therapies, and we always recommend it in the context of your full wellness plan. The logical next step is a consultation where we are honest about fit.
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