What is retatrutide?
Retatrutide is a new medication to treat obesity, diabetes, and fatty liver disease.Created by the pharmaceutical company Lilly, retatrutide is an experimental drug heading toward phase 3 of clinical trials.
Lilly recently announced remarkable results from phase 2 of the trial, revealing better success than similar drugs.
During the trial phase, people with obesity who took the highest dose in the study lost an average of 17.5% of their starting weight after nearly six months — halfway through. By week 48, subjects lost more than 24% — an average of 58 lbs.
In addition, nearly all 338 adult participants who took lower doses of retatrutide saw a 5%–15% weight reduction. This is significant because many healthcare providers recommend losing 5% to 10% of one’s weight over six months to improve blood pressure, cholesterol levels, prediabetes, and metabolic syndrome.
Unsurprisingly, in their June 26, 2023 news release addressing retatrutide trial results, Lilly announced improvements in blood pressure and blood glucose, cholesterol, and insulin levels at weeks 24 and 48 of the trial.
These results make retatrutide the winner among similar drugs. In 2022, another Lilly drug, Mounjaro (tirzepatide), demonstrated 22.5% weight loss after 72 weeks. Previous studies testing semaglutide (Wegovy, Ozempic) showed 15% weight loss in 24 weeks for people with obesity.
Retatrutide works in three ways
Like Wegovy, Mounjaro, and Ozempic, retatrutide helps people lose weight and lower their blood sugar levels. However, Lilly’s clinical trials also demonstrated a powerful third outcome with retatrutide. Results showed significant improvement in non-alcoholic fatty liver disease (NAFLD), a common and dangerous problem for people with obesity and metabolic syndrome.
Because retatrutide works in three ways, it is considered a “tri-agonist.”
1. Helps lower blood sugar
Retatrutide helps address obesity and type 2 diabetes by stimulating insulin release and reducing the release of glucagon (a hormone that increases blood sugar). With more insulin in the blood and less glucagon, blood sugar levels drop, which supports weight loss. Ozempic and Wegovy (semaglutide) work the same way.
2. Promotes weight loss
Retatrutide and Mounjaro double the weight loss action of semaglutide by adding a second weight loss mechanism. Both drugs help suppress appetite and prevent fat accumulation, a benefit neither Ozempic nor Wegovy offer.
3. Improves fatty liver disease
After 48 weeks of treatment during Lilly’s phase 2 of clinical trials, 9 out of 10 patients with NAFLD showed normal amounts of fat in their liver, effectively resolving their fatty liver disease in the short term. This remarkable effect is groundbreaking because 24% of Americans have NAFLD, and no FDA-approved treatments currently exist. Unchecked, NAFLD can lead to liver damage, failure, or cancer.
Surprisingly, to reduce liver fat, retatrutide stimulates the production of glucagon. As noted above, glucagon increases glucose, but it also helps eliminate fat in the liver. At first, this kick in glucagon levels sounds counterproductive. Scientists have yet to understand why fully, but when combined with its two other mechanisms, retatrutide lowers blood sugar levels and excess fatty acids in the liver.
With its impressive weight loss, blood sugar results, and ability to improve fatty liver disease, retatrutide may help many people overcome obesity, type 2 diabetes, NAFLD, and metabolic syndrome.
Is retatrutide safe?
Phase 2 of the clinical trials found similar safety outcomes and side effects as Wegovy, Mounjaro, and Ozempic. Generally, the side effects worsen at higher doses, but it will take time to verify retatrutide’s long-term safety thoroughly.
Retatrutide’s side effects
So far, the most common side effects of retatrutide are gastrointestinal, including:
- Nausea
- Diarrhea
- Vomiting
- Constipation
At higher doses, researchers stated these symptoms were “mostly mild to moderate in severity” and typically treated by lowering the dosage. However, 7% of patients also experienced skin tingling. At 24 weeks of treatment, patients’ heart rates on higher doses peaked but declined afterward.
Risks of taking retutratide
As with every medication, patients and their providers weigh the risks and benefits of treatment. For some patients, the drug’s benefits outweigh the risks. The following are several concerns to consider if contemplating taking retatrutide.
Weight gain after completing treatment
One concern of dieticians is whether patients will regain their weight after completing retatrutide treatment. Ozempic and Wegovy research found that some individuals regained two-thirds of their weight within a year after stopping the medication. Researchers have yet to study this risk for Mounjaro or retatrutide.
These drugs don’t address lifestyle changes
Due to the risk of regaining weight, specialists recommend that patients on weight loss drugs make lifestyle changes to keep the weight off. Similarly, without lifestyle changes, a healed liver may become fatty again for patients with NAFLD.
Potential risk for disordered eating
If one loses weight without lifestyle changes, there is a risk of disordered eating, like binging, after treatment. Focusing on mental health wellness alongside lifestyle changes often creates longer-lasting changes for patients. Studies show that disordered eating and chronic health issues are deeply rooted in mental and spiritual wellness, as defined by finding meaning and inner peace.
The drug treats obesity, not minor weight loss
It’s tempting to ask a doctor for a pill or injection to help lose 10 lbs. However, since medications come with health risks, retatrutide is for those who have serious health issues related to obesity, making the risks of the medication worth the benefit. For those who are not obese but want to lose weight, the good old fashion way of changing one’s diet and exercise is recommended by experts.
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