Everything You Need to Know About NAD+ Supplements

Oxidized nicotinamide adenine dinucleotide (NAD+) is crucial to over 500 enzyme reactions in your body. NAD+ can be derived from tryptophan.

Levels of NAD+ are reduced with aging and conditions like the following:

This article covers the latest evidence for using NAD+ supplements and some safety concerns to be aware of if you decide to use them.

What Is NAD+?

NAD+ is a coenzyme that is important for many pathways in the body, including the following:

It also helps maintain metabolism and circadian rhythm (the 24-hour internal clock regulating sleep cycles).

Significantly, signaling proteins called sirtuins require NAD+ to regulate age-related changes and extend life span.

There aren’t many studies on the effects of NAD+ supplements in humans. So, it is unknown how to dose these supplements. Dosage will depend on your product and what you use it for.

NAD+ can be increased by tryptophan, NMN, NR, and niacin or niacinamide food sources or supplements.

And keep in mind that optimal dosing or duration of NAD+ supplements have not been established yet.


Clinical trials have used the following doses:

  • 250 milligrams (mg) of NMN daily for metabolic benefits in females with prediabetes
  • 1,000 mg of NR daily to improve body composition in people with obesity
  • 1,000 mg of NR daily for Parkinson’s disease